Five's complete shock that she misses him, he always assumes he's the least favorite sibling (you're the only one left here, Five). He'll remind her that he's a call away from blinking up there to see for himself how bad it is so there's no use lying about it. Because it's going awesome where he is, absolutely zero problems.

He's mildly-concerned about her, so he'll probably be pressing her for information until she gets angry at him for being on her all the time, just wait for it.

AND NO he did not cause this apocalypse, you know these things are a group effort.